l IBPM - Genetics @  San Lorenzo
HOMEPAGE PEOPLE PROJECTS MICROSCOPY PUBLICATIONS

Patrizia Lavia

patrizia.lavia@uniroma1.it

Office phone: +39 06 4991 7536
Lab phone: +39 06 49917704; +39 06 4457528
Fax: +39 06 4457529
Laboratories of Via degli Apuli 4, Rome 00185
c/o Sapienza University of Rome

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MITOTIC CONTROL IN MAMMALIAN CELLS


Mitosis is the most critical time in the life of a cell. A dramatic reorganization of cellular structures takes place within a relatively short time (2-3 h in mammalian cells) to enable the formation and function of the mitotic apparatus. The RAN GTPase and Aurora kinases are key players in this reorganization.

Errors in the organization or function of the mitotic apparatus, if not counterselected or corrected in the cell in which they occur, give rise to an abnormal chromosome segregation to daughter cells and initiate a condition of genetic instability, representing a hallmark of cancer cells.

                  
                                                                   
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Our laboratory is interested in the molecular networks that regulate the organization and function of the mitotic apparatus, how these networks operate in space in time and how they might become dysfunctional in transformed cells.