XL system redefines the standards of flow-cytometric analysis. It
combines the analytical power of a research flow cytometer into a
compact clinical analyzer ergonomically designed to expedite sample
The XL system can analyze up to 4 colors
of fluorescence from a single air cooled laser. Multi-color
applications include a broad range of cell biology/functional studies,
- multiparametric DNA analysis to analyse cell cycle
phases, DNA damage and repair, apoptosis, necrosis and mutations in
pathways thereof, detection of cell surface markers in cell lineage
The flexibility to change filter elements increases the versatility of research settings. The XL offers state-of-the-art Digital Signal Processing (DSP)
for reliable linearity and drift-free amplification and compensation.
The single laser design eliminates concerns regarding multi-beam
stability, signal delay and alignment. Compensation is achieved by a
unique digital compensation matrix.
FLOW CYTOMETRY FACILITY PUBLICATIONS
- Fiore M, Degrassi F. (1999) Dimethyl sulfoxide
restores contact inhibition-induced growth arrest and inhibits cell
density-dependent apoptosis in hamster cells. Exp. Cell Res. 25: 102-110
- M Casenghi, R Mangiacasale, M Tuynder, P
Caillet-Fauquet, A Elhajouji, P Lavia, S Mousset, M Kirsch-Volders and
E Cundari (1999) p53-independent apoptosis and p53-dependent block of
DNA rereplication following mitotic spindle inhibition in human cells.
Exp. Cell Res. 250: 339-350.
- Mangiacasale R., Tritarelli A., Sciamanna I.,
Cannone M., Lavia P. Barberis M., Lorenzini R. and Cundari E. (2001).
Normal and cancer-prone human cells respond differently to
extremely low frequency electromagnetic fields. FEBS Letters, 487:
- Fiore M, Zanier R, Degrassi F. (2002) Reversible
G(1) arrest by dimethyl sulfoxide as a new method to synchronize
Chinese hamster cells. Mutagenesis.17:419-24.
- Somma, M. P., Fasulo, B., Cenci, G., Cundari, E.,
and Gatti M. (2002). Molecular dissection of cytokinesis by RNA
interference in Drosophila cultured cells. Mol. Biol. Cell,
- Foglietti C, Filocamo G, Cundari E, De Rinaldis E,
Lahm A, Cortese R, Steinkuhler C. (2006) Dissecting the biological
functions of drosophila histone deacetylases by RNA interference and
transcriptional profiling. J. Biol. Chem. 281(26): 17968-76.
- Mattiuzzo M, Fiore M, Ricordy R, Degrassi F. (2006)
Aneuploidy-inducing capacity of two widely used pesticides.
Carcinogenesis. 27: 2511-8.
- Vernarecci S, Ornaghi P, Bâgu A, Cundari E,
Ballario P, Filetici P. (2008) Gcn5p plays an important role in
centromere kinetochore function in budding yeast. Mol Cell Biol.
- Ferretti C, Totta P, Fiore M, Mattiuzzo M, Schillaci
T, Ricordy R, Di Leonardo A, Degrassi F. (2010) Expression of the
kinetochore protein Hec1 during the cell cycle in normal and cancer
cells and its regulation by the pRb pathway. Cell Cycle. 9:4174-82.
- Romagnoli G, Cundari E, Negri R, Crescenzi M, Farina
L, Giuliani A, Bianchi MM. (2011) Synchronous protein cycling in batch
cultures of the yeast Saccharomyces cerevisiae at log growth phase. Exp
Cell Res. 317:2958-68.